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DL-THIORPHAN

DL-THIORPHAN structure

CAS No.: 76721-89-6

Chemical Name:: DL-THIORPHAN

Synonyms: C01619;THIORPHAN;Thiorphan-d5;DL-THIORPHAN;THIORPHAN (DL);DL-THIORPHAN USP/EP/BP;Bisoprolol FuMarate IMpurity-Q;(DL-3-MERCAPTO-2-BENZYLPROPANOYL)-GLY;(2-benzyl-3-mercaptopropanoyl)glycine;DL-3-MERCAPTO-2-BENZYLPROPANOYL-GLYCINE

CBNumber:: CB0479626

Molecular Formula:: C12H15NO3S

Molecular Weight:: 253.32

MDL Number:: MFCD00058435

MOL File:: 76721-89-6.mol

Last updated:2023-05-04 17:34:42

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DL-THIORPHAN Properties

Melting point	138-140 °C
Boiling point	524.0±50.0 °C(Predicted)
Density	1.246±0.06 g/cm3(Predicted)
RTECS	MC0596440
storage temp.	-15°C
solubility	ethanol: 50 mg/mL, clear, colorless
form	White solid
pka	3.48±0.10(Predicted)
color	White to Off-White
BRN	4872101
CAS DataBase Reference	76721-89-6
FDA UNII	B79L7B5X3Z

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
Safety Statements	22-24/25
WGK Germany	3
F	10
HS Code	29309090

DL-THIORPHAN price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T6031	DL-Thiorphan ≥98% (TLC)	76721-89-6	5mg	$219	2024-03-01	Buy
Sigma-Aldrich	598510	DL-Thiorphan	76721-89-6	10mg	$378	2023-01-07	Buy
Alfa Aesar	J62557	DL-Thiorphan	76721-89-6	25mg	$459.65	2024-03-01	Buy
Cayman Chemical	15600	Thiorphan ≥95%	76721-89-6	5mg	$62	2024-03-01	Buy
Cayman Chemical	15600	Thiorphan ≥95%	76721-89-6	10mg	$115	2024-03-01	Buy

Product number	Packaging	Price	Buy
T6031	5mg	$219	Buy
598510	10mg	$378	Buy
J62557	25mg	$459.65	Buy
15600	5mg	$62	Buy
15600	10mg	$115	Buy

DL-THIORPHAN Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

Thiorphan is a potent inhibitor of neprilysin, a membrane metallo-endopeptidase that cleaves peptide hormones, such as enkephalins, glucagon, and bradykinin (Ki = 4-140 nM). It is much less effective against neprilysin-2 (IC50 = 22.1 μM), angiotensin-converting enzyme, and endothelin-converting enzyme-1. Thiorphan can be produced in vivo via the metabolism of the prodrug acetorphan. Neprilysin is overexpressed in many forms of cancer and may play a role in protecting against Alzheimer’s disease.

Uses

An Enkephalinase inhibitor

Uses

DL-Thiorphan has been used to evaluate the activity of NEP-dependent neutral endopeptidase. DL-Thiorphan has also been used for determining NEP enzymatic activity using fluorimetric assays.

Uses

The active metabolite

Definition

ChEBI: Thiorphan is a N-acyl-amino acid.

General Description

A thiol-containing amido-acid that selectively binds to the active site zinc of neprilysin (also known as neutral endopeptidase and NEP) and inhibits its activity (IC₅₀ = 2.1 nM). Inhibits the β-amyloid (Aβ) degrading activity of neprilysin in vivo, but does not affect the secretion of either Aβ peptide or amyloid precursor protein (APP). Also shown to inhibit other neprilysin-related family members, such as mouse NL1 (IC₅₀ = 47 nM) and the neprilysin homolog from Ascaris suum (IC₅₀ = 22 μM). Inhibits the activity of angiotensin-converting enzyme (ACE) (IC₅₀ = 140 nM), but has no effect on the activity of endothelin-converting enzyme (ECE).

Biochem/physiol Actions

Primary TargetNEP activity

DL-THIORPHAN Preparation Products And Raw materials

Raw materials

Preparation Products

DL-THIORPHAN Suppliers

Global( 115)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
GL Biochem (Shanghai) Ltd.	+86-021-61263370 +86-18901917034		CHINA	3904	58
GL Biochem(Binhai) Ltd.	+86-021-61263370 +8615301650015	wuqiuyan@glschina.com	China	2975	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	28455	58
Shenzhen Shengda Pharma Limited	755-85269922 +8613424394241	sales@shengdapharm.com	CHINA	310	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58

Supplier	Advantage
Hubei xin bonus chemical co. LTD	58
Standardpharm Co. Ltd.	58
BOC Sciences	58
Career Henan Chemica Co	58
GL Biochem (Shanghai) Ltd.	58
GL Biochem(Binhai) Ltd.	58
Dideu Industries Group Limited	58
Shenzhen Shengda Pharma Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Nextpeptide Inc	58

76721-89-6(DL-THIORPHAN)Related Search:

Zinc glycinate Ferrous Bisglycinate Trimethylglycine Glycine Benzylmalonic acid

Deacetyl Racecadotril Disulfide Benzyl glycinate p-toluenesulfonate ACETYL SULFIDE Thiorphan Disulfide Diethyl benzylmalonate

Racecadotril Diacid Impurity Racecadotril N-P-TOSYLGLYCINE BENZYL ESTER Thioacetic acid Glycine, N-[1-oxo-2-(phenylmethyl)-3-[(1-thioxoethyl)thio]propyl]-, phenylmethyl ester

2-Benzylacrylic acid Acrylic acid Racecadotril Impurity 14

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N-[(RS)-2-BENZYL-3-MERCAPTOPROPANOYL]-GLYCINE (+/-)-N-(3-MERCAPTO-2-BENZYLPROPIONYL)GLYCINE N-ALPHA-(DL-3-MERCAPTO-2-BENZYLPROPANOYL)-GLYCINE THIORPHAN THIORPHAN (DL) ((RS)-2-BENZYL-3-MERCAPTOPROPIONYL)-GLYCINE ((RS)-2-BENZYL-3-MERCAPTOPROPIONYL)-GLY-OH 2-Mercaptomethyl-3-phenyl-propionylamino-acetic Acid, D,L-3-Mercapto-2-benzylpropanoylglycine, (±)-N-(3-Mercapto-2-benzylpropionyl)glycine, DL-3-Mercapto-2-benzylpropanoylglycine rac-N-[(2R*)-3-Mercapto-2-benzylpropionyl]glycine C01619 2-MercaptoMethyl-3-phenylpropionylaMinoacetic Acid N-[2-(MercaptoMethyl)-1-oxo-3-phenylpropyl]glycine 2-[[2-(Benzyl)-3-sulfanylpropanoyl]aMino]acetic acid 2-(2-benzyl-3-MercaptopropanaMido)acetic acid (DL-3-Mercapto-2-benzylpropionyl)-Gly-OH, (DL-3-Mercapto-2-benzylpropanoyl)-Gly-OH Bisoprolol FuMarate IMpurity-Q Thiorphan-d5 (DL-3-MERCAPTO-2-BENZYLPROPANOYL)-GLY DL-3-MERCAPTO-2-BENZYLPROPANOYL-GLYCINE (DL-3-MERCAPTO-2-BENZYLPROPANOYL)-GLY-OH DL-THIORPHAN DL-Thiorphan - CAS 76721-89-6 - Calbiochem Racecadotril Impurity 2（Racecadotril EP Impurity B） 2-(2-benzyl-3-sulfanylpropanamido)acetic acid Racecadotril impurity 1/Racecadotril EP impurity B/Thiorphan/[[(2RS)-2-benzyl-3-sulfanylpropanoyl]amino]acetic acid Glycine, N-[2-(mercaptomethyl)-1-oxo-3-phenylpropyl]- 2-[(2-benzyl-3-sulfanylpropanoyl)amino]aceticaci DL-THIORPHAN USP/EP/BP (2-benzyl-3-mercaptopropanoyl)glycine [[(2RS)-2-benzyl-3-sulfanylpropanoyl]amino]acetic acid 76721-89-6 25332 Enzyme Inhibitors Enkephalinase BioChemical Biochemicals and Reagents Organic Covalent Modifiers Enzyme Inhibitors by Enzyme Enzyme Inhibitors by Type Enzymes, Inhibitors, and Substrates D to K Aromatics Amino Acids 13C, 2H, 15N Amino Acids & Derivatives Inhibitors Sulfur & Selenium Compounds